Reverse signaling through the Co-Stimulatory Ligand, CD137L, as a critical mediator of sterile inflammation
نویسندگان
چکیده
منابع مشابه
Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.
Renal ischemia-reperfusion injury (IRI) after kidney transplantation is a major cause of delayed graft function. Even though IRI is recognized as a highly coordinated and specific process, the pathways and mechanisms through which the innate response is activated are poorly understood. In this study, we used a mouse model of acute kidney IRI to examine whether the interactions of costimulatory ...
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15 صفحه اولComplement as a Mediator of Inflammation
Interaction in free solution of highly purified preparations of human C'1 esterase, C'4, C'2, and C'3, in the presence of Mg(2+), resulted in rapid generation of an activity indistinguishable by biological criteria from anaphylatoxin. The formation of anaphylatoxin was associated with immunoelectrophoretic conversion of C'3 to anodically faster migrating proteins and was unaffected by the prese...
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ژورنال
عنوان ژورنال: Molecules and Cells
سال: 2012
ISSN: 1016-8478,0219-1032
DOI: 10.1007/s10059-012-0077-3